Chemical Process Research and Development, Amgen Inc., Thousand Oaks, California 91320, USA.
J Am Chem Soc. 2010 Mar 24;132(11):3674-5. doi: 10.1021/ja100354j.
Heteroarenes are important structural moieties in many chemical industry fields. A highly efficient Pd/Cu-catalyzed C-H arylation method for a range of heterocycles has been discovered. It was found that the key to the success of this transformation is a combination of a palladium catalyst and a well-defined copper cocatalyst. The efficiency and low loadings of catalyst (0.25 mol %) and cocatalyst (1 mol %) together with the mild reaction conditions demonstrate this method to be practically useful and mechanistically interesting.
杂芳烃是许多化学工业领域的重要结构单元。现已发现一种高效的 Pd/Cu 催化的杂环 C-H 芳基化方法。研究发现，这种转化成功的关键是钯催化剂和定义明确的铜助催化剂的结合。催化剂（0.25mol%）和助催化剂（1mol%）的效率和低负载量以及温和的反应条件表明该方法具有实际应用价值和有趣的反应机理。
