McDonald Stacey L, Hendrick Charles E, Wang Qiu
Department of Chemistry, Duke University, Durham, NC 27708-0346 (USA).
Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4667-70. doi: 10.1002/anie.201311029. Epub 2014 Mar 25.
Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.
通过一锅法C-H锌化/铜催化亲电胺化过程实现了杂芳烃和芳烃的直接胺化。这种胺化方法提供了一种高效且快速的途径来获得多种杂芳族和芳族胺,包括那些以前使用C-H胺化方法无法获得的胺。温和的反应条件和良好的官能团兼容性证明了其在合成重要和复杂胺方面的巨大潜力。