Center for Substance Abuse Research (CESAR), University of Maryland, College Park, Maryland 20740, USA.
Am J Drug Alcohol Abuse. 2009;35(4):233-41. doi: 10.1080/00952990903005957.
Heavy drinking and illicit drug use among college students has been a longstanding public health concern. Current methods to screen and identify college students at-risk for the development of substance use disorders (SUD) are somewhat limited.
This study aimed to cross-validate the work by Kirisci et al. ( [1] ), who developed the Transmissible Liability Index (TLI), by deriving a set of items that would be potentially useful for characterizing SUD risk across multiple dimensions among college students. We examined: 1) variations in the TLI-College Version (TLI-CV) by race, sex, SES, religiosity, and family history of substance use problems; 2) the association between the TLI-CV and alcohol and/or marijuana dependence, both cross-sectionally and prospectively, by race and sex; and, 3) the sensitivity and specificity of the TLI-CV for identifying cases of marijuana and/or alcohol dependence.
Data from an ongoing longitudinal study of college students (n = 1,253) was used to conduct item response theory (IRT) analyses; the resulting TLI-CV consisted of 33 items.
The TLI-CV was significantly associated with baseline dependence and significantly higher for non-dependent individuals who later became dependent during the subsequent three years of college. These associations were observed for both sexes, Whites, Blacks/African-Americans, Asians, and other racial minorities. The sensitivity and specificity were suboptimal.
The TLI-CV advances prior research to identify college students at risk for SUD. This approach holds potential promise to identify and ultimately modify the trajectories of college students who may be at risk for the development of SUD.
大学生酗酒和非法药物滥用一直是一个长期存在的公共卫生问题。目前，用于筛查和识别有发展物质使用障碍（SUD）风险的大学生的方法有些有限。
本研究旨在通过推导一组可能有助于描述大学生 SUD 风险的跨多个维度的项目，对 Kirisci 等人的工作进行交叉验证。[1]，他们开发了可传播责任指数（TLI）。我们检查了：1）TLI-College 版本（TLI-CV）在种族、性别、SES、宗教信仰和家庭物质使用问题史方面的差异；2）TLI-CV 与酒精和/或大麻依赖之间的横断面和前瞻性关联，按种族和性别划分；3）TLI-CV 识别大麻和/或酒精依赖病例的敏感性和特异性。
使用一项正在进行的大学生纵向研究的数据进行项目反应理论（IRT）分析；由此产生的 TLI-CV 由 33 个项目组成。
TLI-CV 与基线依赖显著相关，对于在随后的三年大学生活中后来变得依赖的非依赖个体，TLI-CV 显著更高。这些关联在男性、女性、白人、黑人/非裔美国人、亚洲人和其他少数族裔中都有观察到。敏感性和特异性不理想。
TLI-CV 推进了先前的研究，以识别有 SUD 风险的大学生。这种方法有可能识别并最终改变可能有发展 SUD 风险的大学生的轨迹。
