Endocrinology Clinic, Hippokration Hospital, Thessaloniki, Greece.
Curr Vasc Pharmacol. 2010 Sep;8(5):720-30. doi: 10.2174/157016110792006978.
Vitamin D deficiency is a well-established risk factor for bone disease. Emerging data suggest a pleiotropic role of this agent in a variety of functions in humans. Epidemiological studies indicate an inverse association between vitamin D deficiency and the prevalence of cardiovascular disease (CVD), as well as individual cardiometabolic risk factors, such as hypertension, diabetes, dyslipidemia and the metabolic syndrome. Moreover, vitamin D deficiency has been implicated in the atherosclerotic process. This review considers current data regarding the role of vitamin D deficiency in the development of CVD and addresses the effect of supplementation on cardiovascular outcomes.
维生素 D 缺乏是一种公认的骨骼疾病风险因素。新出现的数据表明，这种物质在人类的多种功能中具有多效性作用。流行病学研究表明，维生素 D 缺乏与心血管疾病（CVD）的流行以及高血压、糖尿病、血脂异常和代谢综合征等个体心血管代谢危险因素呈负相关。此外，维生素 D 缺乏与动脉粥样硬化过程有关。这篇综述考虑了关于维生素 D 缺乏在 CVD 发展中的作用的现有数据，并探讨了补充剂对心血管结局的影响。
