Department of Cardiology, Children's Hospital Affiliated to Capital Institute of Pediatrics, 100020, Beijing, China.
Department of Epidemiology, Capital Institute of Pediatrics, 100020, Beijing, China.
J Hum Hypertens. 2022 Jul;36(7):604-609. doi: 10.1038/s41371-021-00622-4. Epub 2022 Jan 9.
Researchers have shown that 25-hydroxyvitamin D (25[OH] D), a kind of active vitamin D in the human body, plays a role in cardiovascular disease (CVD). Low serum 25(OH) D levels have been found to be associated with elevated blood pressure (BP) in adults. However, measurement of 25(OH) D in hypertensive children has not been documented. The aim of this study was to investigate the relationship between 25(OH) D and target organ damage (TOD) in children with essential hypertension. We recruited a total of 346 children with essential hypertension and analyzed the correlation between serum 25(OH) D and TOD. Serum 25(OH) D concentration was significantly lower in the TOD than in the no-TOD group (t = 2.416, P = 0.016), as well as significantly lower in the two-organ damage than in the single-organ damage group (t = 3.140, P = 0.002). Pearson's correlation coefficient (PCC) indicated that serum 25(OH) D levels were negatively correlated with left ventricular mass index (LVMI; r = -0.110, P = 0.041) and albuminuria (r = -0.120, P = 0.026). Linear- regression analysis showed that 25(OH) D was a risk factor for left ventricular hypertrophy (LVH; β ± s.e. =-0.074 ± 0.036; 95% confidence interval [CI], - 0.145 to -0.003; P < 0.001) and renal damage (β ± s.e.= -0.018 ± 0.008; 95% CI, - 0.035 to -0.002; P = 0.004). In total, our data revealed that serum 25(OH) D was independently associated with hypertensive cardiac and renal damage, meaning that it was a risk factor for LVH and albuminuria in childhood hypertension.
研究人员表明，25- 羟维生素 D（25[OH]D），一种人体中的活性维生素 D，在心血管疾病（CVD）中发挥作用。低血清 25（OH）D 水平与成人血压升高有关。然而，高血压儿童的 25（OH）D 测量尚未有文献记录。本研究旨在探讨原发性高血压儿童 25（OH）D 与靶器官损害（TOD）之间的关系。我们共招募了 346 名原发性高血压儿童，并分析了血清 25（OH）D 与 TOD 之间的相关性。TOD 组血清 25（OH）D 浓度明显低于非 TOD 组（t=2.416，P=0.016），且两器官损伤组明显低于单器官损伤组（t=3.140，P=0.002）。Pearson 相关系数（PCC）表明，血清 25（OH）D 水平与左心室质量指数（LVMI；r=-0.110，P=0.041）和蛋白尿（r=-0.120，P=0.026）呈负相关。线性回归分析表明，25（OH）D 是左心室肥厚（LVH；β±s.e.= -0.074±0.036；95%置信区间 [CI]，-0.145 至 -0.003；P<0.001）和肾脏损伤（β±s.e.= -0.018±0.008；95% CI，-0.035 至 -0.002；P=0.004）的危险因素。总的来说，我们的数据表明，血清 25（OH）D 与高血压性心脏和肾脏损害独立相关，这意味着它是儿童高血压中 LVH 和蛋白尿的危险因素。
