Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Intern Med J. 2010 May;40(5):323-34. doi: 10.1111/j.1445-5994.2010.02192.x. Epub 2010 Feb 18.
Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification.
尽管现代治疗方法已经问世，但慢性重度哮喘仍然是一个具有挑战性的临床问题。重度哮喘中存在相对的皮质激素不敏感性，这可能导致疾病持续加重。对皮质激素不敏感的分子机制的深入理解可能会产生新的治疗靶点。此外，已经确定了皮质激素不敏感的病因因素，这些因素可能可以通过修饰来改变。
