Alvarez-Gutiérrez Francisco Javier, Blanco-Aparicio Marina, Casas-Maldonado Francisco, Plaza Vicente, González-Barcala Francisco Javier, Carretero-Gracia José Ángel, Castilla-Martínez Manuel, Cisneros Carolina, Diaz-Pérez David, Domingo-Ribas Christian, Martínez-Moragon Eva, Muñoz Xavier, Padilla-Galo Alicia, Perpiñá-Tordera Miguel, Soto-Campos Gregorio
Unidad de Asma, UMQER, Hospital Universitario Virgen del Rocío, Sevilla, España.
Servicio de Neumología, Hospital Universitario A Coruña, A Coruña, España.
Open Respir Arch. 2022 Jul 2;4(3):100192. doi: 10.1016/j.opresp.2022.100192. eCollection 2022 Jul-Sep.
Severe asthma is a heterogeneous syndrome with several clinical variants and often represents a complex disease requiring a specialized and multidisciplinary approach, as well as the use of multiple drugs. The prevalence of severe asthma varies from one country to another, and it is estimated that 50% of these patients present a poor control of their disease. For the best management of the patient, it is necessary a correct diagnosis, an adequate follow-up and undoubtedly to offer the best available treatment, including biologic treatments with monoclonal antibodies. With this objective, this consensus process was born, which began in its first version in 2018, whose goal is to offer the patient the best possible management of their disease in order to minimize their symptomatology. For this 2020 consensus update, a literature review was conducted by the authors. Subsequently, through a two-round interactive Delphi process, a broad panel of asthma experts from SEPAR and the regional pulmonology societies proposed the recommendations and conclusions contained in this document.
重度哮喘是一种具有多种临床变体的异质性综合征,通常是一种复杂疾病,需要采用专门的多学科方法,并使用多种药物。重度哮喘的患病率因国家而异,据估计,这些患者中有50%的病情控制不佳。为了对患者进行最佳管理,正确的诊断、充分的随访以及无疑要提供最佳可用治疗(包括单克隆抗体生物治疗)是必要的。出于这一目的,这一共识流程应运而生,其首个版本始于2018年,目标是为患者提供尽可能最佳的疾病管理,以减轻其症状。对于本次2020年共识更新,作者进行了文献综述。随后,通过两轮交互式德尔菲法流程,来自西班牙呼吸学会(SEPAR)和各地区肺病学会的广泛哮喘专家小组提出了本文件中的建议和结论。