International Trypanotolerance Centre, Banjul, The Gambia.
Trop Med Int Health. 2010 Apr;15(4):476-9. doi: 10.1111/j.1365-3156.2010.02470.x. Epub 2010 Feb 17.
To determine whether epilepsy is caused by Taenia solium cysticercosis in The Gambia.
Case-control study testing samples collected from 210 people with epilepsy and 420 matched controls by sex and age +/-5 years from 69 different places around the country during the period October 2008-March 2009. All serum samples were subjected to an antigen detection ELISA (Ag-ELISA) and electro-immunotransfer blot (EITB), and the seropositives were further CT-scanned to determine the presence of cysticerci in the brain.
Although not significantly different (P = 0.668), circulating Taenia antigen was found by Ag-ELISA in 1.4% (95% CI: 0.3-4.1) of people with epilepsy and in 1.9% (95% CI: 0.8-3.7) of the controls. A non-significant (P = 0.4718) odds ratio of association 0.75 (95% CI: 0.13-3.15) between epilepsy and the presence of Taenia antigens was found. All 630 serum samples turned out seronegative by the EITB test. There were no intracranial cysts or cyst-like structures detected among the nine CT-scanned Ag-ELISA seropositives.
Epilepsy appears not to be caused by cysticercosis in The Gambia.
在冈比亚确定癫痫是否由猪带绦虫囊尾蚴引起。
病例对照研究，于 2008 年 10 月至 2009 年 3 月期间，在全国 69 个不同地点，按性别和年龄（+/-5 岁）对 210 名癫痫患者和 420 名匹配对照者采集样本进行检测。所有血清样本均进行抗原检测 ELISA（Ag-ELISA）和电免疫转移印迹（EITB）检测，对血清阳性者进一步进行 CT 扫描，以确定脑内是否存在囊虫。
虽然差异无统计学意义（P=0.668），但 Ag-ELISA 发现癫痫患者中循环绦虫抗原的检出率为 1.4%（95%CI：0.3-4.1），对照组中为 1.9%（95%CI：0.8-3.7）。发现癫痫与绦虫抗原存在之间的关联无统计学意义（P=0.4718），比值比为 0.75（95%CI：0.13-3.15）。EITB 检测结果显示，所有 630 份血清样本均为阴性。在 9 名 Ag-ELISA 血清阳性者中进行 CT 扫描，均未发现颅内囊肿或囊状结构。
在冈比亚，癫痫似乎不是由囊尾蚴病引起的。
