Department of Human Morphology and Biomedical Sciences Città Studi, Laboratory of Clinical Pathology, University of Milan, Milan, Italy.
Immun Ageing. 2010 Jan 25;7:2. doi: 10.1186/1742-4933-7-2.
The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis, or even a total lack of atherosclerotic changes, in DS AIM: The aim of our study is to investigate the relationship between age and brain-derived neurotrophic factor (BDNF) levels in Down Syndrome (DS).
Three groups of DS patients were studied: the first consisted of 23 children (age 2-14 years); the second of 14 adults (age 20-50 years), the third group of 13 elderly persons (>60 years) and a controls group of 20 healthy patients (age 15-60 years).The analytes of interest were quantified using a biochip array analyzer (Evidence, Randox Ltd., Crumlin, UK).
Plasma BDNF was higher in DS patients than in controls and there was a significant age-related increase. Serum levels of IL-6 and MCP-1 were also higher in DS children and adults, but not in older patients, than in healthy control. High levels of circulating BDNF may protect DS patients from the clinical complications of atherosclerosis. However, the striking drop in peripheral BDNF levels with age might predispose these patients to clinical manifestations of dementia in later life.
唐氏综合征（DS）患者的冠心病患病率较低，且很少死于动脉粥样硬化并发症。组织病理学研究表明，DS 患者的动脉粥样硬化无增加，甚至完全缺乏动脉粥样硬化改变。
本研究旨在探讨唐氏综合征（DS）患者年龄与脑源性神经营养因子（BDNF）水平的关系。
研究了三组 DS 患者：第一组由 23 名儿童（年龄 2-14 岁）组成；第二组由 14 名成年人（年龄 20-50 岁）组成，第三组由 13 名老年人（>60 岁）组成，对照组为 20 名健康患者（年龄 15-60 岁）。使用生物芯片阵列分析仪（英国克鲁姆林兰卓克斯公司的 Evidence）定量分析感兴趣的分析物。
DS 患者的血浆 BDNF 高于对照组，且与年龄呈正相关。DS 儿童和成年人的血清 IL-6 和 MCP-1 水平也高于健康对照组，但老年患者则不然。循环 BDNF 水平升高可能使 DS 患者免受动脉粥样硬化临床并发症的影响。然而，外周 BDNF 水平随年龄的显著下降可能使这些患者在以后的生活中易发生痴呆的临床表现。
