Department of Biochemistry and Molecular Biology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Ital J Pediatr. 2010 Feb 9;36:16. doi: 10.1186/1824-7288-36-16.
Celiac disease (CD) emerged as a public health problem, and the disease prevalence varies among different races. The present study was designed to investigate the prevalence of CD using serological markers in apparently healthy schoolchildren in Irbid City, Jordan. Additionally, the effect of positive serology on height, weight and body mass index (BMI) was evaluated.
The study population consisted of 1985 children (1117 girls and 868 boys), age range was 5.5 to 9.5 years. Height and weight were measured and blood samples were collected from each individual. Serum samples were analyzed for IgA anti-tissue transglutaminase antibodies (tTG) using a commercial enzyme-linked immunosorbent assay (ELISA). tTG positive samples were further analyzed for IgA anti-endomysium antibodies (EmA) with a commercial ELISA. Samples confirmed positive with EmA were considered seropositive.
Sixteen children were CD positive. The serological prevalence was estimated to be 1:124 (0.8%; 95% CI, 0.5% to 1.3%). Significant impact on growth (height) was found in seropositive children. When both sexes were individually analyzed, only boys showed height reduction. Furthermore, seropositive boys also had a significant weight reduction.
This study demonstrated that CD is prevalent among schoolchildren in Jordan. The seropositive children tend to have lower height, weight, and BMI than the seronegative group. These differences were significant only for boys. None of the participants is known to have CD prior to the study.
乳糜泻（CD）已成为一个公共卫生问题，且该病在不同种族中的流行率存在差异。本研究旨在通过血清学标志物调查约旦伊尔比德市健康学龄儿童中 CD 的流行率。此外，还评估了阳性血清学对身高、体重和体重指数（BMI）的影响。
研究人群由 1985 名儿童（1117 名女孩和 868 名男孩）组成，年龄范围为 5.5 至 9.5 岁。测量身高和体重，并从每个个体采集血样。使用商业酶联免疫吸附试验（ELISA）分析血清样本中的 IgA 抗组织转谷氨酰胺酶抗体（tTG）。tTG 阳性样本进一步使用商业 ELISA 分析 IgA 抗内肌膜抗体（EmA）。EmA 阳性样本被认为是血清阳性。
16 名儿童 CD 阳性。血清流行率估计为 1:124（0.8%；95%CI，0.5%至 1.3%）。在血清阳性儿童中发现生长（身高）有显著影响。当对男女分别进行分析时，只有男孩的身高降低。此外，血清阳性男孩的体重也显著减轻。
本研究表明，CD 在约旦学龄儿童中普遍存在。血清阳性儿童的身高、体重和 BMI 往往低于血清阴性组。这些差异仅在男孩中具有统计学意义。在研究之前，没有已知的参与者患有 CD。
