Nutrition Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil.
Early Hum Dev. 2010 Feb;86(2):127-31. doi: 10.1016/j.earlhumdev.2010.02.002. Epub 2010 Feb 23.
To assess the relationship between cortisol concentrations in the last trimester of pregnancy and systemic vascular resistance - SVR in childhood.
This study is part of a cohort involving 130 Brazilian pregnant women and their children, ages 5 to 7years. Maternal cortisol was determined in saliva by an enzyme immunoassay utilizing the mean concentration of 9 samples of saliva (3 in each different day), collected at the same time, early in the morning. SVR was assessed by the HDI/PulseWave CR-2000 Cardiovascular Profiling System(R). Socioeconomic and demographic characteristics and life style factors were determined by a questionnaire. The nutritional status of the women and children was assessed by the body mass index - BMI. The association between maternal cortisol and SVR in childhood was calculated by multivariate linear regression analysis.
There were statistically significant associations between maternal cortisol and SVR (p=0.043) and BMI-z score of the children (p=0.027), controlling for maternal BMI, birth weight, age, and gender of the children.
As far as we know this is the first study in the literature assessing the association between cortisol concentrations in pregnancy and SVR in childhood. Overall, the data suggest that exposure to excess glucocorticoid in the prenatal period is associated to vascular complications in childhood, predisposing to cardiovascular diseases in later life.
评估妊娠晚期皮质醇浓度与儿童时期全身血管阻力（SVR）之间的关系。
本研究是一项队列研究的一部分，涉及 130 名巴西孕妇及其 5 至 7 岁的儿童。通过酶联免疫吸附试验（ELISA）利用唾液中 9 个样本的平均浓度（每天 3 个）来测定孕妇的皮质醇，这些样本均在清晨同一时间采集。使用 HDI/PulseWave CR-2000 心血管特征分析系统（R）评估 SVR。通过问卷调查确定社会经济和人口统计学特征以及生活方式因素。通过体重指数（BMI）评估妇女和儿童的营养状况。通过多元线性回归分析计算母亲皮质醇与儿童 SVR 之间的相关性。
在校正母亲 BMI、出生体重、儿童年龄和性别后，母亲皮质醇与 SVR（p=0.043）和儿童 BMI-z 评分（p=0.027）之间存在统计学显著关联。
据我们所知，这是文献中第一项评估妊娠期间皮质醇浓度与儿童时期 SVR 之间关系的研究。总体而言，数据表明，产前暴露于过多的糖皮质激素与儿童期血管并发症有关，使成年后易患心血管疾病。
