Gutteling Barbara M, de Weerth Carolina, Buitelaar Jan K
Department of Psychiatry, Radboud University Nijmegen, Medical Center, The Netherlands.
Stress. 2004 Dec;7(4):257-60. doi: 10.1080/10253890500044521.
In this study influences of maternal prenatal stress on the cortisol reactions of children to a vaccination were determined. Prenatal stress at around 16 weeks of gestation was measured through questionnaires and a cortisol day curve. Cortisol reactions were determined preceding and following the vaccination. A total of 24 children (age between 3.11 and 5.9 years, mean age 4.9 years) and their mothers participated in this study. Multilevel analysis (hierarchical linear modelling) was used to analyze the data. Children of mothers who had higher concentrations of morning cortisol during pregnancy had higher concentrations of cortisol as compared to children of mothers who had lower concentrations of morning cortisol. Furthermore, more daily hassles and a higher level of fear of bearing a handicapped child during pregnancy were associated with higher concentrations of cortisol in the children.
在本研究中，确定了母亲产前压力对儿童接种疫苗时皮质醇反应的影响。通过问卷调查和皮质醇日曲线测量妊娠约16周时的产前压力。在接种疫苗前后测定皮质醇反应。共有24名儿童（年龄在3.11岁至5.9岁之间，平均年龄4.9岁）及其母亲参与了本研究。采用多水平分析（分层线性模型）对数据进行分析。与孕期早晨皮质醇浓度较低的母亲的孩子相比，孕期早晨皮质醇浓度较高的母亲的孩子皮质醇浓度更高。此外，更多的日常琐事以及孕期对生下残疾儿童的更高恐惧水平与儿童更高的皮质醇浓度相关。
