Groven Nina, Fors Egil Andreas, Stunes Astrid Kamilla, Reitan Solveig Klæbo
Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Psychiatry and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway.
Brain Behav Immun Health. 2020 Mar 28;4:100067. doi: 10.1016/j.bbih.2020.100067. eCollection 2020 Apr.
The role of the immune system in the pathogenesis of Fibromyalgia (FM) and Chronic fatigue syndrome (CFS) is not clear. We have previously reported increased levels of C-reactive protein (CRP) in these patient groups compared to healthy controls and wanted to further explore the levels of circulating immune markers in these populations. The population consisted of three groups, 58 patients with FM, 49 with CFS and 54 healthy controls. All participants were females aged 18-60. Patients were recruited from a specialised university hospital clinic and controls were recruited by advertisement among the staff and students at the hospital and university. Plasma levels of Interferon (IFN)-γ, Interleukin (IL)-1β, IL-1ra, IL-4, IL-6, IL-8, IL-10, IL-17, Interferon gamma-induced protein (IP)-10, Monocyte Chemoattractant Protein (MCP)-1, Transforming Growth Factor (TGF)-β1, TGF-β2, TGF-β3 and Tumour Necrosis Factor (TNF)-α were analysed by multiplex. Differences between the three groups CFS, FM and controls, were analysed by Kruskal Wallis tests. MCP-1 was significantly increased in both patient groups compared to healthy controls. IL-1β, Il-4, IL-6, TNF-α, TGF-β1, TGF-β2, TGF-β3, IL-10 and IL17 all were significantly lower in the patient groups than healthy controls. IFN-γ was significantly lower in the FM group. For IL-8, IL-10 and IL-1ra there were no significant difference when controlled for multiple testing. In conclusion, in our material MCP-1 seems to be increased in patients both with CFS and with FM, while several other immune markers are significantly lower in patients than controls.
免疫系统在纤维肌痛（FM）和慢性疲劳综合征（CFS）发病机制中的作用尚不清楚。我们之前曾报道，与健康对照组相比，这些患者组中C反应蛋白（CRP）水平升高，并且想要进一步探究这些人群中循环免疫标志物的水平。研究人群包括三组，58例FM患者、49例CFS患者和54名健康对照者。所有参与者均为18至60岁的女性。患者从一家专业大学医院诊所招募，对照者通过在医院和大学的工作人员及学生中发布广告招募。通过多重分析检测血浆中干扰素（IFN）-γ、白细胞介素（IL）-1β、IL-1ra、IL-4、IL-6、IL-8、IL-10、IL-17、干扰素γ诱导蛋白（IP）-10、单核细胞趋化蛋白（MCP）-1、转化生长因子（TGF）-β1、TGF-β2、TGF-β3和肿瘤坏死因子（TNF）-α的水平。通过Kruskal Wallis检验分析CFS、FM和对照组这三组之间的差异。与健康对照组相比，两个患者组中的MCP-1均显著升高。患者组中的IL-1β、IL-4、IL-6、TNF-α、TGF-β1、TGF-β2、TGF-β3、IL-10和IL-17均显著低于健康对照组。FM组中的IFN-γ显著降低。对于IL-8、IL-10和IL-1ra，在进行多重检验校正后无显著差异。总之，在我们的研究材料中，CFS和FM患者的MCP-1似乎升高，而患者的其他几种免疫标志物显著低于对照组。
