Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520-8034, USA.
J Natl Cancer Inst. 2010 Apr 7;102(7):502-5. doi: 10.1093/jnci/djq007. Epub 2010 Feb 24.
Carriage of a non-O ABO blood group and colonization by Helicobacter pylori are thought to be risk factors for pancreatic cancer. We examined these associations in a population-based case-control study of 373 case patients and 690 control subjects frequency matched on sex and age. Control subjects were selected by random-digit dialing. Seropositivity for H pylori and its virulence protein CagA was determined by enzyme-linked immunosorbent assay (ELISA). Increased risk of pancreatic cancer was associated with non-O blood group (adjusted odds ratio [OR] = 1.37, 95% confidence interval [CI] = 1.02 to 1.83, P = .034) and CagA-negative H pylori seropositivity (OR = 1.68, 95% CI = 1.07 to 2.66, P = .025), but no association was observed for CagA seropositivity (OR = 0.77, 95% CI = 0.52 to 1.16). An association between pancreatic cancer risk and CagA-negative H pylori seropositivity was found among individuals with non-O blood type but not among those with O blood type (OR = 2.78, 95% CI = 1.49 to 5.20, P = .0014; OR = 1.28, 95% CI = 0.62 to 2.64, P = .51, respectively). This study demonstrates an association between pancreatic cancer and H pylori colonization, particularly for individuals with non-O blood types.
携带非 O 型 ABO 血型和幽门螺杆菌定植被认为是胰腺癌的危险因素。我们在一项基于人群的病例对照研究中对 373 名病例患者和 690 名按性别和年龄频数匹配的对照进行了这些关联的研究。对照通过随机数字拨号选择。通过酶联免疫吸附试验（ELISA）检测 H pylori 及其毒力蛋白 CagA 的血清阳性率。胰腺癌风险与非 O 型血型相关（调整后的比值比[OR] = 1.37，95%置信区间[CI] = 1.02 至 1.83，P =.034）和 CagA 阴性 H pylori 血清阳性（OR = 1.68，95% CI = 1.07 至 2.66，P =.025），但 CagA 血清阳性与胰腺癌风险无关（OR = 0.77，95% CI = 0.52 至 1.16）。在非 O 型血型的个体中发现了胰腺癌风险与 CagA 阴性 H pylori 血清阳性之间的关联，但在 O 型血型的个体中没有发现这种关联（OR = 2.78，95% CI = 1.49 至 5.20，P =.0014；OR = 1.28，95% CI = 0.62 至 2.64，P =.51）。本研究表明，H pylori 定植与胰腺癌之间存在关联，特别是对于非 O 型血型的个体。
