de Martel Catherine, Llosa Augusto E, Friedman Gary D, Vogelman Joseph H, Orentreich Norman, Stolzenberg-Solomon Rachael Z, Parsonnet Julie
Department of Health Research and Policy, Stanford University School of Medicine, 300 Pasteur Road, Stanford, CA 94305, USA.
Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1188-94. doi: 10.1158/1055-9965.EPI-08-0185.
Infection with Helicobacter pylori is an established risk factor for gastric cancer. Results from two studies suggest that it may also be a risk factor for pancreatic cancer.
We conducted a nested case control study among 128,992 adult subscribers to the Kaiser Permanente Medical Care Program who had been enrolled in a multiphasic health checkup from 1964 to 1969. Serum collected during the checkup was maintained frozen, and subjects were followed for cancer. Cases consisted of 104 randomly selected subjects among 507 who developed pancreatic cancer in the cohort. Controls consisted of 262 pancreatic cancer-free subjects from a pool of 730 controls previously tested for studies conducted on this cohort. Controls were individually matched to cases on age, gender, race, site, and date of multiphasic health checkup. Control sera were compared with cases for antibodies to H. pylori and the CagA protein. The effects of smoking, alcohol consumption, obesity, and years of education were also investigated.
Neither H. pylori [odds ratio (OR), 0.85; 95% confidence interval (95% CI), 0.49-1.48] nor its CagA protein (OR, 0.96; 95% CI, 0.48-1.92) was associated with subsequent development of pancreatic cancer. Smoking (OR, 2.09; 95% CI, 1.17-3.74) and greater number of years of education (OR, 2.13; 95% CI, 1.23-3.69) were risk factors for pancreatic cancer, whereas alcohol consumption and obesity were not.
Our results suggest that H. pylori infection is not associated with development of pancreatic cancer.
幽门螺杆菌感染是胃癌的既定危险因素。两项研究结果表明，它也可能是胰腺癌的危险因素。
我们在1964年至1969年参加多阶段健康检查的128,992名凯撒医疗保健计划成年订阅者中进行了一项巢式病例对照研究。检查期间采集的血清被冷冻保存，对受试者进行癌症随访。病例包括该队列中507例患胰腺癌的患者中随机选取的104例。对照由来自此前针对该队列进行的研究中730名对照样本库中的262名无胰腺癌的受试者组成。对照按年龄、性别、种族、地点和多阶段健康检查日期与病例进行个体匹配。将对照血清与病例血清进行比较，检测幽门螺杆菌抗体和CagA蛋白。还研究了吸烟、饮酒、肥胖和受教育年限的影响。
幽门螺杆菌[比值比（OR），0.85；95%置信区间（95%CI），0.49 - 1.48]及其CagA蛋白（OR，0.96；95%CI，0.48 - 1.92）均与随后发生的胰腺癌无关。吸烟（OR，2.09；95%CI，1.17 - 3.74）和受教育年限较长（OR，2.13；95%CI，1.23 - 3.69）是胰腺癌的危险因素，而饮酒和肥胖则不是。
我们的结果表明，幽门螺杆菌感染与胰腺癌的发生无关。
