Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research and Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
J Alzheimers Dis. 2010;20(3):803-11. doi: 10.3233/JAD-2010-091624.
There is increasing evidence that some lifestyle factors are linked to the development of Alzheimer's disease. Many of these are potentially modifiable and include smoking, physical activity, education, social engagement, cognitive stimulation, and diet. Modification of most of these factors has other health advantages, increasing the potential benefits of modifying the individual's lifestyle. Unfortunately, most of the current evidence is based on observational data, and where human trials have been performed they have used surrogate outcomes rather than the development of Alzheimer's disease. For many of these modifiable lifestyle factors, such trials may never be performed, and an individual's choice may need to be based on the available evidence.
越来越多的证据表明，一些生活方式因素与阿尔茨海默病的发展有关。其中许多因素是潜在可改变的，包括吸烟、身体活动、教育、社会参与、认知刺激和饮食。大多数这些因素的改变都有其他健康益处，增加了改变个人生活方式的潜在益处。不幸的是，目前的大多数证据都基于观察性数据，而且在进行人体试验时，它们使用的是替代结果，而不是阿尔茨海默病的发展。对于许多这些可改变的生活方式因素，可能永远不会进行这样的试验，个人的选择可能需要基于现有证据。
