Department of Psychiatry, Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia.
Alzheimers Dement. 2010 May;6(3):291-6. doi: 10.1016/j.jalz.2010.03.009.
The Australian Imaging Biomarkers and Lifestyle (AIBL) study is a longitudinal study of 1112 volunteers from healthy, mild cognitive impairment, and Alzheimer's disease (AD) populations who can be assessed and followed up for prospective research into aging and AD. AIBL aims to improve understanding of the pathogenesis, early clinical manifestation, and diagnosis of AD, and identify diet and lifestyle factors that influence the development of AD. For AIBL, the magnetic resonance imaging parameters of Alzheimer's Disease Neuroimaging Initiative (ADNI) were adopted and the Pittsuburgh compound B ((11)C-PiB) positron emission tomography (PET) acquisition and neuropsychological tests were designed to permit comparison and pooling with ADNI data. Differences to ADNI include assessment every 18-months, imaging in 25% (magnetic resonance imaging, (11)C-PiB PET but no fluorodeoxyglucose PET), more comprehensive neuropsychological testing, and detailed collection of diet and lifestyle data. AIBL has completed the first 18-month follow-up and is making imaging and clinical data available through the ADNI website. Cross-sectional analysis of baseline data is revealing links between cognition, brain amyloid burden, structural brain changes, biomarkers, and lifestyle.
澳大利亚成像生物标志物和生活方式（AIBL）研究是一项针对 1112 名志愿者的纵向研究，这些志愿者来自健康人群、轻度认知障碍人群和阿尔茨海默病（AD）人群，可以对其进行评估和随访，以便对衰老和 AD 进行前瞻性研究。AIBL 的目标是提高对 AD 发病机制、早期临床表现和诊断的理解，并确定影响 AD 发展的饮食和生活方式因素。对于 AIBL，采用了阿尔茨海默病神经影像学倡议（ADNI）的磁共振成像参数，并设计了匹兹堡化合物 B（(11)C-PiB）正电子发射断层扫描（PET）采集和神经心理学测试，以允许与 ADNI 数据进行比较和合并。与 ADNI 的不同之处包括每 18 个月进行一次评估、25%的影像学检查（磁共振成像、(11)C-PiB PET 但无氟脱氧葡萄糖 PET）、更全面的神经心理学测试以及详细的饮食和生活方式数据收集。AIBL 已经完成了第一次 18 个月的随访，并通过 ADNI 网站提供成像和临床数据。对基线数据的横断面分析揭示了认知、大脑淀粉样蛋白负担、结构脑变化、生物标志物和生活方式之间的联系。
