Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands.
J Alzheimers Dis. 2010;20 Suppl 1:S143-50. doi: 10.3233/JAD-2010-091228.
People with diabetes mellitus are at increased risk of cognitive dysfunction. This review explores the relation between caffeine intake, diabetes, cognition and dementia, focusing on type 2 diabetes (T2DM). Epidemiological studies on caffeine/coffee intake and T2DM risk are reviewed. Next, the impact of T2DM on cognition is addressed. Finally, the potential for caffeine to modulate the risk of cognitive decline in the context of diabetes is explored. The conclusion is that, although epidemiological studies indicate that coffee/caffeine consumption is associated with a decreased risk of T2DM and possibly also with a decreased dementia risk, we can at present not be certain that these associations are causal. For now, recommendations for coffee consumption in individuals with T2DM or pre-diabetic stages are therefore difficult to establish, but it should be acknowledged that caffeine does appear to have several properties that warrant further investigations in this field.
糖尿病患者认知功能障碍的风险增加。本综述探讨了咖啡因摄入、糖尿病、认知和痴呆之间的关系，重点关注 2 型糖尿病（T2DM）。我们回顾了咖啡因/咖啡摄入量与 T2DM 风险的流行病学研究。接下来，我们讨论了 T2DM 对认知的影响。最后，我们探讨了咖啡因在糖尿病背景下调节认知能力下降风险的可能性。结论是，尽管流行病学研究表明咖啡/咖啡因的摄入与 T2DM 风险降低有关，也可能与痴呆风险降低有关，但我们目前不能确定这些关联是否具有因果关系。目前，对于 T2DM 或糖尿病前期个体的咖啡摄入量的建议因此难以确定，但应该承认，咖啡因似乎具有一些特性，值得在这一领域进行进一步研究。
