Lichtor J L, Zacny J, Korttila K, Apfelbaum J L, Lane B S, Rupani G, Thisted R A, Dohrn C
Department of Anesthesia, University of Chicago, Illinois 60637.
Anesth Analg. 1991 May;72(5):661-6. doi: 10.1213/00000539-199105000-00016.
Patients who arrive home several hours after ambulatory surgery may drink alcohol. The extent to which the residual effects of drugs used in ambulatory surgery interact with alcohol, perhaps potentiating alcohol effects, is not known. Accordingly, the purpose of this study was to determine whether intravenous midazolam had residual effects that would interact with alcohol consumed 4 h after the midazolam injection. Healthy male volunteers (n = 16) participated in a double-blind, randomized, placebo-controlled crossover trial. Subjects were studied four times successively with 1 wk between trials. On each test day the subjects randomly received by slow intravenous injection (30 s) either saline or 0.1 mg/kg of midazolam. Four hours after injection, the subjects consumed a beverage that either did or did not contain 0.7 g/kg of alcohol. Before and 1, 3, 5, and 7 h after injection (and before and 1 and 3 h after beverage consumption), psychomotor performance and mood were assessed. Whereas both midazolam and alcohol alone had effects on the dependent measures in this study, there were no significant interactions between the two drugs (i.e., potentiation of alcohol effects by midazolam or potentiation of midazolam by alcohol). We conclude that the effects of a short-acting benzodiazepine used in ambulatory surgery have probably dissipated by the time a patient arrives home, and that effects from alcohol ingested at home will probably not be influenced by the recent administration of a short-acting benzodiazepine such as midazolam.
门诊手术后数小时才回家的患者可以饮酒。门诊手术中使用的药物残留效应与酒精相互作用的程度，或许会增强酒精的作用，目前尚不清楚。因此，本研究的目的是确定静脉注射咪达唑仑是否具有残留效应，该效应会与咪达唑仑注射4小时后摄入的酒精发生相互作用。健康男性志愿者（n = 16）参与了一项双盲、随机、安慰剂对照的交叉试验。受试者连续接受四次研究，每次试验间隔1周。在每个测试日，受试者通过缓慢静脉注射（30秒）随机接受生理盐水或0.1mg/kg的咪达唑仑。注射后4小时，受试者饮用一种含有或不含有0.7g/kg酒精的饮料。在注射前以及注射后1、3、5和7小时（以及饮用饮料前和饮用后1和3小时），评估心理运动表现和情绪。尽管在本研究中，咪达唑仑和酒精单独使用时均对相关测量指标有影响，但两种药物之间没有显著的相互作用（即咪达唑仑增强酒精作用或酒精增强咪达唑仑作用）。我们得出结论，门诊手术中使用的短效苯二氮䓬类药物的效应在患者回家时可能已经消散，并且在家中摄入酒精的影响可能不会受到近期使用短效苯二氮䓬类药物（如咪达唑仑）的影响。
