Lichtor J L, Zacny J P, Coalson D W, Flemming D C, Uitvlugt A, Apfelbaum J L, Lane B S, Thisted R A
Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637.
Anesthesiology. 1993 Jul;79(1):28-35. doi: 10.1097/00000542-199307000-00007.
During ambulatory surgery, barbiturates, such as thiopental, may impair psychomotor performance several hours after administration. It was hypothesized that if patients drink alcohol 4 h after thiopental injection, the increase in psychomotor impairment would be greater than that seen after alcohol ingestion alone.
Twelve healthy men volunteered to participate in a double-blind, placebo-controlled, crossover study with a Latin square design. On each testing day, the subjects received intravenous injections of either 5 mg/kg of 2.5% thiopental or an equal volume of saline for 30 s. Four hours after injection, the subjects consumed a beverage with or without 0.7 g/kg alcohol. Psychomotor performance and mood were assessed at five times: prior to injection, at 1 h and 3 h after injection, and at 1 h and 3 h after consumption of beverage.
Both thiopental and alcohol had strong independent effects on the dependent measures in this study. In addition, body sway, one of the nine psychomotor tests used to assess impairment, was greater after thiopental and alcohol than after alcohol alone. Of eleven adjectives used to assess mood, lightheadedness was cited most frequently after a combination of thiopental and alcohol than after each alone.
Based on our tests of performance and mood, an interaction between thiopental and alcohol is evident; in addition, the interaction between both drugs may exert deleterious effects on higher levels of central nervous system integration.
在门诊手术期间，巴比妥类药物，如硫喷妥钠，在给药数小时后可能会损害精神运动表现。据推测，如果患者在硫喷妥钠注射4小时后饮酒，精神运动损害的增加将大于单独饮酒后的情况。
12名健康男性志愿者参与了一项采用拉丁方设计的双盲、安慰剂对照、交叉研究。在每个测试日，受试者接受静脉注射5mg/kg的2.5%硫喷妥钠或等体积的生理盐水，持续30秒。注射4小时后，受试者饮用含或不含0.7g/kg酒精的饮料。在五个时间点评估精神运动表现和情绪：注射前、注射后1小时和3小时，以及饮用饮料后1小时和3小时。
在本研究中，硫喷妥钠和酒精对相关测量指标均有强烈的独立影响。此外，用于评估损害的九项精神运动测试之一的身体摇摆，在硫喷妥钠和酒精联合作用后比单独饮酒后更大。在用于评估情绪的十一个形容词中，硫喷妥钠和酒精联合作用后比单独使用每种药物后更频繁地出现头晕。
基于我们对表现和情绪的测试，硫喷妥钠和酒精之间的相互作用是明显的；此外，两种药物之间的相互作用可能会对中枢神经系统更高水平的整合产生有害影响。
