Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, 71110 Heraklion, Greece.
Mediators Inflamm. 2009;2009:812102. doi: 10.1155/2009/812102. Epub 2010 Feb 23.
Little is known about the longitudinal effects of smoking cessation on sputum inflammatory cells. We aimed to investigate the changes in sputum inflammatory cells and T-lymphocyte subpopulations after 6 and 12 months smoking cessation. Induced sputum was obtained from 68 healthy smokers before and after 6 months (n = 21) and 1 year (n = 14) smoking cessation and from ten healthy never-smokers. Inflammatory cells were identified by morphology and T-lymphocyte subpopulations by flow cytometry. Sputum macrophages were decreased after 12 months of smoking cessation in comparison to baseline, while neutrophils increased. Moreover, CD8+ T-cells were decreased in smokers before smoking cessation compared to never-smokers and increased in smokers after 6 months of smoking cessation in comparison to baseline; result that was maintained after 1 year of smoking cessation. These novel findings indicate that smoking cessation can equilibrate certain inflammatory cells of smokers with those of nonsmokers, within 6 months of smoking cessation.
关于戒烟对痰中炎症细胞的纵向影响知之甚少。我们旨在研究戒烟 6 个月和 12 个月后痰中炎症细胞和 T 淋巴细胞亚群的变化。我们从 68 名健康吸烟者中获得了诱导痰，这些吸烟者在戒烟前（n=21）和戒烟 6 个月后（n=14）以及 10 名从未吸烟的健康人中进行了研究。通过形态学和流式细胞术鉴定炎症细胞和 T 淋巴细胞亚群。与基线相比，戒烟 12 个月后，痰中的巨噬细胞减少，而中性粒细胞增加。此外，与从不吸烟者相比，戒烟前的吸烟者 CD8+T 细胞减少，而戒烟 6 个月后与基线相比增加；这一结果在戒烟 1 年后仍保持不变。这些新发现表明，戒烟可以在 6 个月内使吸烟者的某些炎症细胞与不吸烟者的炎症细胞相平衡。
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