Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001834. doi: 10.1101/cshperspect.a001834.
Neuronal migration is, along with axon guidance, one of the fundamental mechanisms underlying the wiring of the brain. As other organs, the nervous system has acquired the ability to grow both in size and complexity by using migration as a strategy to position cell types from different origins into specific coordinates, allowing for the generation of brain circuitries. Guidance of migrating neurons shares many features with axon guidance, from the use of substrates to the specific cues regulating chemotaxis. There are, however, important differences in the cell biology of these two processes. The most evident case is nucleokinesis, which is an essential component of migration that needs to be integrated within the guidance of the cell. Perhaps more surprisingly, the cellular mechanisms underlying the response of the leading process of migrating cells to guidance cues might be different to those involved in growth cone steering, at least for some neuronal populations.
神经元迁移是大脑布线的基本机制之一，与轴突导向一样。与其他器官一样，神经系统通过使用迁移作为一种策略，将来自不同起源的细胞类型定位到特定的坐标，从而获得了生长的能力，从而增加了大小和复杂性。迁移神经元的导向与轴突导向有许多共同的特征，从使用基质到调节趋化性的特定线索。然而，这两个过程的细胞生物学有重要的区别。最明显的例子是核迁移，它是迁移的一个基本组成部分，需要整合到细胞的导向中。也许更令人惊讶的是，迁移细胞的前导过程对导向线索的反应的细胞机制可能与生长锥转向所涉及的机制不同，至少对于某些神经元群体是这样。
