Xu Shizhong, Hu Zhiqiu
Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA.
Int J Plant Genomics. 2009;2009:410825. doi: 10.1155/2009/410825. Epub 2010 Feb 21.
Quantitative trait locus (QTL) mapping is usually performed using markers that follow a Mendelian segregation ratio. We developed a new method of QTL mapping that can use markers with segregation distortion (non-Mendelian markers). An EM (expectation-maximization) algorithm is used to estimate QTL and SDL (segregation distortion loci) parameters. The joint analysis of QTL and SDL is particularly useful for selective genotyping. Application of the joint analysis is demonstrated using a real life data from a wheat QTL mapping experiment.
数量性状基因座（QTL）定位通常使用遵循孟德尔分离比例的标记来进行。我们开发了一种新的QTL定位方法，该方法可以使用具有分离畸变的标记（非孟德尔标记）。期望最大化（EM）算法用于估计QTL和分离畸变基因座（SDL）参数。QTL和SDL的联合分析对于选择性基因分型特别有用。使用来自小麦QTL定位实验的实际数据展示了联合分析的应用。
