Abbasi M A, Lodhi M A, Ahmad V U, Choudhary M I
Department of Chemistry, Center for Natural Product Drug Development, Government College University, Lahore, Pakistan.
J Asian Nat Prod Res. 2009 Nov;11(11):933-9. doi: 10.1080/10286020903321539.
The mechanism of inhibition of the alpha-chymotrypsin enzyme by two lignans of the fused bistetrahydrofuran series, epiexcelsin (1) and 5'-demethoxyepiexcelsin (2), which were isolated from the Commiphora mukul Engl., was investigated. Lineweaver-Burk and Dixon plots and their secondary replots showed that these compounds were noncompetitive inhibitors of the enzyme. K(i) values for 1 and 2 were found to be 22.29 +/- 0.015 and 336.30 +/- 0.053 microM, respectively.
研究了从没药（Commiphora mukul Engl.）中分离出的稠合双四氢呋喃系列的两种木脂素，表异巴西灵（1）和5'-去甲氧基表异巴西灵（2）对α-糜蛋白酶的抑制机制。Lineweaver-Burk图和Dixon图及其二次重绘图表明，这些化合物是该酶的非竞争性抑制剂。发现1和2的K(i)值分别为22.29±0.015和336.30±0.053 microM。
