来自姜黄根茎的三种新型萜类化合物。

Three novel terpenoids from the rhizomes of Curcuma longa.

作者信息

Li Wei, Feng Jia-Tao, Xiao Yuan-Sheng, Wang Ya-Qin, Xue Xing-Ya, Liang Xin-Miao

机构信息

Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

出版信息

J Asian Nat Prod Res. 2009 Jun;11(6):569-75. doi: 10.1080/10286020902939182.

DOI:10.1080/10286020902939182

PMID:20183292

Abstract

Investigation of the EtOH extract of the rhizomes of Curcuma longa led to the isolation of two new sesquiterpenes, 2-methoxy-5-hydroxybisabola-3,10-diene-9-one (1) and 2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), one new monoterpene, 2-(2,5-dihydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), together with five known sesquiterpenes (4-8). Among the known compounds, bisacurone A (5) and 4-methylene-5-hydroxybisabola-2,10-diene-9-one (6) were isolated from C. longa and genus Curcuma for the first time, respectively. Their structures were established on the basis of various spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR, IR spectra, and by comparison of their spectral data with those of related compounds.

摘要

对姜黄根茎的乙醇提取物进行研究，从中分离出两种新的倍半萜，即2-甲氧基-5-羟基双环[3.1.1]庚-3,10-二烯-9-酮（1）和2,8-环氧-5-羟基双环[3.1.1]庚-3,10-二烯-9-酮（2），一种新的单萜，2-(2,5-二羟基-4-甲基环己-3-烯基)丙酸（3）以及五种已知的倍半萜（4-8）。在这些已知化合物中，双莪术酮A（5）和4-亚甲基-5-羟基双环[3.1.1]庚-2,10-二烯-9-酮（6）分别首次从姜黄和姜黄属植物中分离得到。它们的结构是基于包括高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D和2D NMR）、红外光谱（IR）等多种光谱分析，并通过将其光谱数据与相关化合物的数据进行比较而确定的。