海南粗榧内生真菌S20的代谢产物
Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis.
作者信息
Dai Wen-Jun, Wu Jiao, Han Zhuang, Mei Wen-Li, Dai Hao-Fu
机构信息
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
出版信息
J Asian Nat Prod Res. 2009 Aug;11(8):704-9. doi: 10.1080/10286020902858846.
Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.
从海南粗榧（Cephalotaxus hainanensis Li）的内生真菌S20中分离出三种新的C-甲基化产乙酸菌素，即(2E,6Z)-9,10-二羟基-4-羟甲基-2,6-癸二烯（1）、(2E,6Z)-8,9,10-三羟基-4-羟甲基-2,6-癸二烯（2）和(2E,6Z)-9-羟基-4-羟甲基-2,6-壬二烯（3），以及两种已知化合物，对羟基苯甲醇（4）和吲哚-3-羧酸（5）。通过高分辨电喷雾电离质谱（HR-ESI-MS）和光谱技术（红外光谱、紫外光谱、一维和二维核磁共振）确定了它们的结构。采用滤纸片琼脂扩散法，化合物5对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌显示出抑制作用。
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