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天然产物对多重耐药病原体的抗菌潜力：综述

Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review.

作者信息

Elmaidomy Abeer H, Shady Nourhan Hisham, Abdeljawad Khaled Mohamed, Elzamkan Mohamed Badran, Helmy Hussein Hykel, Tarshan Emad Ashour, Adly Abanoub Nabil, Hussien Yasmin Hamdy, Sayed Nesma Gamal, Zayed Ahmed, Abdelmohsen Usama Ramadan

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University Beni-Suef 62511 Egypt.

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone New Minia 61111 Egypt.

出版信息

RSC Adv. 2022 Oct 13;12(45):29078-29102. doi: 10.1039/d2ra04884a. eCollection 2022 Oct 11.

DOI:10.1039/d2ra04884a
PMID:36320761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9558262/
Abstract

Antibiotic resistance is one of the critical issues, describing a significant social health complication globally. Hence, the discovery of novel antibiotics has acquired an increased attention particularly against drug-resistant pathogens. Natural products have served as potent therapeutics against pathogenic bacteria since the glorious age of antibiotics of the mid 20th century. This review outlines the various mechanistic candidates for dealing with multi-drug resistant pathogens and explores the terrestrial phytochemicals isolated from plants, lichens, insects, animals, fungi, bacteria, mushrooms, and minerals with reported antimicrobial activity, either alone or in combination with conventional antibiotics. Moreover, newly established tools are presented, including prebiotics, probiotics, synbiotics, bacteriophages, nanoparticles, and bacteriocins, supporting the progress of effective antibiotics to address the emergence of antibiotic-resistant infectious bacteria. Therefore, the current article may uncover promising drug candidates that can be used in drug discovery in the future.

摘要

抗生素耐药性是一个关键问题，它描述了全球范围内严重的社会健康并发症。因此，新型抗生素的发现尤其受到了更多关注，特别是针对耐药病原体。自20世纪中叶抗生素的辉煌时代以来，天然产物一直是对抗病原菌的有效疗法。这篇综述概述了应对多重耐药病原体的各种机制候选物，并探索了从植物、地衣、昆虫、动物、真菌、细菌、蘑菇和矿物质中分离出的具有抗菌活性的陆地植物化学物质，这些物质可单独使用或与传统抗生素联合使用。此外，还介绍了新建立的工具，包括益生元、益生菌、合生元、噬菌体、纳米颗粒和细菌素，这些工具支持有效抗生素的研发，以应对抗生素耐药性感染细菌的出现。因此，当前的文章可能会揭示出未来可用于药物发现的有前景的候选药物。

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