Dai Wen-jun, Dai Hao-fu, Wu Jiao, Liu Jian, Mei Wen-li
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, PR China.
Nat Prod Commun. 2009 Nov;4(11):1489-90.
A new 5-acyl-2-methylpyrrole, isolated from the endophytic fungus S20 of Cephalotaxus hainanensis, was elucidated as 1-(5-methyl-1H-pyrrol-2-yl)-2-((2S*,3R*)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone (1) on the basis of spectroscopic evidence, including 1D- and 2D-NMR (HMQC, 1H-1H COSY, HMBC and ROESY) and MS analysis. Compound 1 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.
从海南粗榧内生真菌S20中分离出一种新的5-酰基-2-甲基吡咯，基于光谱证据（包括一维和二维核磁共振谱（HMQC、1H-1H COSY、HMBC和ROESY）以及质谱分析），将其鉴定为1-(5-甲基-1H-吡咯-2-基)-2-((2S*,3R*)-3-((E)-丙-1-烯基)环氧乙烷-2-基)乙酮（1）。通过滤纸片琼脂扩散法，化合物1对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌显示出抑制作用。
