Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA.
J Clin Child Adolesc Psychol. 2009 Nov;38(6):814-25. doi: 10.1080/15374410903297148.
This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments.
本文探讨了家庭环境和亲子冲突等方面，这些方面可能会预测或调节抑郁青少年（N=439）对急性治疗的反应，这些青少年被随机分配到氟西汀、认知行为疗法、两者的联合治疗或安慰剂组。结果是在抑郁和总体障碍的测量上，第 12 周的得分。在 20 个候选变量中，出现了一个预测因素：在所有治疗中，母亲报告亲子冲突较少的青少年比对照组更有可能受益。当家庭功能调节结果时，那些对环境持更消极看法的青少年更有可能从氟西汀中受益。同样，当在认知行为治疗条件下观察到调节作用时，它们对报告家庭环境较差的青少年的效果更差。
