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为什么对寄生虫的免疫力需要很长时间才能形成？

Why does immunity to parasites take so long to develop?

出版信息

Nat Rev Immunol. 2010 Feb;10(2):80-1. doi: 10.1038/nri2673.

DOI:10.1038/nri2673
PMID:20183893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437742/
Abstract

‘Maria Yazdanbakhsh and David Sacks discuss the various immune evasion strategies employed by human parasite pathogens to secure their transmission and that underlie the chronicity of infection and disease.’

摘要

‘玛丽亚·亚兹丹巴什和大卫·萨克斯讨论了人类寄生虫病原体为确保传播而采用的各种免疫逃避策略，这些策略是感染和疾病慢性化的基础。’

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本文引用的文献

1
Regulation of pathogenesis and immunity in helminth infections.蠕虫感染中发病机制与免疫的调节
J Exp Med. 2009 Sep 28;206(10):2059-66. doi: 10.1084/jem.20091903. Epub 2009 Sep 21.
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Animal defenses against infectious agents: is damage control more important than pathogen control.动物对传染原的防御：损害控制比病原体控制更重要吗？
PLoS Biol. 2008 Dec 23;6(12):e4. doi: 10.1371/journal.pbio.1000004.
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Acquired immunity to malaria.获得性疟疾免疫力。
Clin Microbiol Rev. 2009 Jan;22(1):13-36, Table of Contents. doi: 10.1128/CMR.00025-08.
4
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases.抵御感染的两种方式：抗性和耐受性能为我们治疗传染病带来的启示。
Nat Rev Immunol. 2008 Nov;8(11):889-95. doi: 10.1038/nri2432.
5
Immunity to malaria: more questions than answers.对疟疾的免疫：问题多于答案。
Nat Immunol. 2008 Jul;9(7):725-32. doi: 10.1038/ni.f.205.
6
Interleukin-10 and the pathogenesis of human visceral leishmaniasis.白细胞介素-10与人类内脏利什曼病的发病机制
Trends Immunol. 2007 Sep;28(9):378-84. doi: 10.1016/j.it.2007.07.004. Epub 2007 Aug 6.
7
The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria.恶性疟原虫感染红细胞表面抗原抗体在疟疾自然获得性免疫中的作用。
Trends Microbiol. 2002 Feb;10(2):55-8. doi: 10.1016/s0966-842x(01)02278-8.
8
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.白细胞介素（IL）-10在愈合后皮肤中杜氏利什曼原虫持续存在中的作用以及抗IL-10受体抗体实现无菌治愈的治疗潜力。
J Exp Med. 2001 Nov 19;194(10):1497-506. doi: 10.1084/jem.194.10.1497.
9
Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age.免疫初免移民人群中针对曼氏血吸虫抗体同种型反应的发展：感染持续时间、感染强度和宿主年龄的影响
Infect Immun. 1999 Jul;67(7):3444-51. doi: 10.1128/IAI.67.7.3444-3451.1999.
10
Immunity to non-cerebral severe malaria is acquired after one or two infections.对非脑型重症疟疾的免疫力在感染一两次后获得。
Nat Med. 1999 Mar;5(3):340-3. doi: 10.1038/6560.