Reeder J C, Brown G V
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Immunol Cell Biol. 1996 Dec;74(6):546-54. doi: 10.1038/icb.1996.88.
Plasmodium falciparum malaria is responsible for 2 million deaths each year. Even in endemic regions, immunity to malaria builds slowly and is rarely complete. Strategies such as antigenic variation and antigenic diversity are critical to a parasite's ability to evade the host immune response and infect previously exposed individuals. In this short review, the phenomenon of antigenic variation is discussed in relation to immune evasion and its impact on parasite pathogenesis. Recent advances in the understanding of the underlying molecular mechanisms of antigenic variation are examined and questions posed for future research.
恶性疟原虫每年导致200万人死亡。即使在疟疾流行地区，对疟疾的免疫力形成缓慢，且很少能完全形成。抗原变异和抗原多样性等策略对于寄生虫逃避宿主免疫反应并感染先前接触过的个体的能力至关重要。在这篇简短的综述中，讨论了抗原变异现象与免疫逃避及其对寄生虫发病机制的影响。研究了对抗原变异潜在分子机制理解的最新进展，并提出了未来研究的问题。
