Asian Studies Network (ASNET), Division for International Relations, The University of Tokyo, Tokyo, Japan.
Hum Genet. 2010 Mar;127(3):287-94. doi: 10.1007/s00439-009-0768-9.
Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI > or = 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a signiWcantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.
几十年来，各种太平洋岛屿人群的肥胖患病率显著增加。本研究探讨了肥胖基因（LEP）启动子多态性 G-2548A（rs7799039）和瘦素受体基因（LEPR）的两个非同义单核苷酸多态性 K109R（rs1137100）和 Q223R（rs1137101）与体重、体重指数（BMI）和肥胖（BMI≥30）在太平洋岛民中的相关性。在调整年龄、性别和人群差异后，对 745 名讲南岛语系（AN）的参与者进行了分析。结果表明，LEPR 的 223Q 等位基因携带者的体重（P=0.0009）和 BMI（P=0.0022）明显高于非携带者（即 223R 纯合子）；此外，与非携带者相比，223Q 携带者肥胖的风险也显著更高（P=0.0222）。其他两个多态性 G-2548A 和 K109R 与体重、BMI 或肥胖均无关。223Q 等位基因在讲南岛语系的研究对象中广泛存在，因此提示 LEPR Q223R 多态性是导致太平洋岛民肥胖患病率高的因素之一。
