Radulović Niko S, Blagojević Polina D, Skropeta Danielle, Zarubica Aleksandra R, Zlatković Bojan K, Palić Radosav M
Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia.
Nat Prod Commun. 2010 Jan;5(1):121-7.
Tansy, Tanacetum macrophyllum (Waldst. & Kit.) Sch. Bip., is often misidentified by herb collectors as yarrow, Achillea grandifolia Friv. With the former, cases of poisoning induced by its ingestion are well documented, but the latter is widely used for ethnopharmacological purposes. The aim of this study was to estimate, based on the volatile metabolite profiles of the two species, the potential health risk connected with their misidentification. GC and GC-MS analysis of the essential oils hydrodistilled using a Clevenger-type apparatus from A. grandifolia, T. macrophyllum, and two plant samples (reputedly of A. grandifolia, but in fact mixtures of A. grandifolia and T. macrophyllum) obtained from a local market, resulted in the identification of 215 different compounds. The main constituents of A. grandifolia oil were ascaridole (15.5%), alpha-thujone (7.5%), camphor (15.6%), borneol (5.2%) and (Z)-jasmone (6.4%), and of T. macrophyllum oil, 1,8-cineole (8.6%), camphor (6.4%), borneol (9.1%), isobornyl acetate (9.5%), copaborneol (4.2%) and gamma-eudesmol (6.2%). The compositions of the oils extracted from the samples obtained from the market were intermediate to those of A. grandifolia and T. macrophyllum. Significant differences in the corresponding volatile profiles and the literature data concerning the known activities of the pure constituents of the oils, suggested that the pharmacological action of the investigated species (or their unintentional mixtures) would be notably different. It seems, however, that misidentification of T. macrophyllum as A. grandifolia does not represent a health risk and that the absence of the toxic alpha-thujone from T. macrophyllum oil may in fact be regarded as a benefit.
艾菊，大花菊蒿（Waldst. & Kit.）Sch. Bip.，常被草药采集者误认作大叶酸模，千叶蓍。关于前者，其摄入导致中毒的案例有充分记录，但后者被广泛用于民族药理学目的。本研究的目的是基于这两个物种的挥发性代谢物谱，评估与其误认相关的潜在健康风险。使用克利夫enger型装置对大叶酸模、大花菊蒿以及从当地市场获得的两个植物样本（据称是大叶酸模，但实际上是大叶酸模和大花菊蒿的混合物）进行水蒸馏提取精油，并进行气相色谱（GC）和气相色谱 - 质谱（GC - MS）分析，结果鉴定出215种不同化合物。大叶酸模油的主要成分是驱虫菊酯（15.5%）、α - 侧柏酮（7.5%）、樟脑（15.6%）、冰片（5.2%）和（Z）- 茉莉酮（6.4%），大花菊蒿油的主要成分是1,8 - 桉叶素（8.6%）、樟脑（6.4%）、冰片（9.1%）、乙酸异龙脑酯（9.5%）、异龙脑香醇（4.2%）和γ - 桉叶醇（6.2%）。从市场获得的样本中提取的油的成分介于大叶酸模和大花菊蒿之间。相应挥发性谱的显著差异以及关于油的纯成分已知活性的文献数据表明，所研究物种（或其无意的混合物）的药理作用会有显著不同。然而，将大花菊蒿误认作大叶酸模似乎并不代表健康风险，而且大花菊蒿油中不含有毒的α - 侧柏酮实际上可能被视为一种益处。
