Alexandrescu V, Hubermont G, Coessens V, Philips Y, Guillaumie B, Ngongang Chr, Vincent G, Azdad K, Ledent G, De Marre C, Macoir C
Department of Vascular and Thoracic Surgery, Princesse Paola Hospital Marche-en-Famenne, Belgium.
Acta Chir Belg. 2009 Nov-Dec;109(6):694-700. doi: 10.1080/00015458.2009.11680519.
INTRODUCTION/AIM OF THE STUDY: To assess the influence of a multidisciplinary approach on the limb salvage rates in the treatment of patients suffering from diabetic ischaemic inferior limb ulcers.
MATERIALS & METHOD: From September 2001 until March 2008, a consecutive series of 183 limbs with diabetic ischaemic wounds in 163 patients were treated by combined multi-level angioplasties as the primary revascularization approach in an institutional diabetic programme (two departmental hospitals). The avoidance of limb loss was retrospectively analyzed before and after the year 2005, as a landmark for implementing a "multidisciplinary diabetic foot clinic" in the routine daily care.
Initial technical success for endovascular revascularization was noted in 152 limbs (83%). The aggregate limb salvage proportions at 12, 24, 32, 60 and 66 months (+/- SEM) were: 87% (+/- 2.8), 80% (+/- 3.9), 77% (+/- 4.4) and thereafter 77% (+/- 4.4), respectively. A comparison between the limb salvage rates before and after initiating the multidisciplinary group showed a significant difference (p = 0.040, CI: 1.040-5.311, HR: 2.35, Chi square = 4.22) with better results in the latest interval, employing effective team activity. No statistical deviation was found regarding the technique itself for revascularization at the same intervals (p = 0.381).
Our experience suggests that limb salvage for diabetic ischaemic wounds may be favourably influenced by a co-ordinated multidisciplinary group. Although appropriate revascularization is crucial for limb rescue, a pluralist control of the attending risk factors influencing wound healing might be of matchless importance as well.
研究的引言/目的:评估多学科方法对糖尿病缺血性下肢溃疡患者肢体挽救率的影响。
从2001年9月至2008年3月,在一个机构性糖尿病项目(两家部门医院)中,对163例患者的183条患有糖尿病缺血性伤口的肢体采用联合多级血管成形术作为主要的血运重建方法进行治疗。以2005年为界,回顾性分析在常规日常护理中实施“多学科糖尿病足诊所”前后避免肢体缺失的情况。
血管内血运重建的初始技术成功率在152条肢体中得以体现(83%)。在12、24、32、60和66个月(±标准误)时的总体肢体挽救比例分别为:87%(±2.8)、80%(±3.9)、77%(±4.4),此后为77%(±4.4)。启动多学科小组前后的肢体挽救率比较显示出显著差异(p = 0.040,置信区间:1.040 - 5.311,风险比:2.35,卡方 = 4.22),在最近时间段采用有效的团队活动取得了更好的结果。在相同时间段内,关于血运重建技术本身未发现统计学偏差(p = 0.381)。
我们的经验表明,协调的多学科小组可能对糖尿病缺血性伤口的肢体挽救产生有利影响。尽管适当的血运重建对于挽救肢体至关重要,但对影响伤口愈合的相关危险因素进行多元化控制可能同样具有无比重要的意义。