Yoneshima Yasuto, Hirano Satoshi, Morino Eriko, Takeda Yuichiro, Sugiyama Haruhito, Kobayashi Nobuyuki, Kudo Koichiro
Department of Respiratory Medicine, International Medical Center of Japan, Toyama Hospital.
Nihon Kokyuki Gakkai Zasshi. 2010 Feb;48(2):118-22.
A 75-year-old man had been given a diagnosis of small cell lung cancer (SCLC) in March 2005. He had been treated with chemotherapy consisting of carboplatin and etoposide, and he had showed partial response to treatment. He presented with general fatigue, weakness of the muscles and extremities, skin lesions and finger erythema in April 2006. A muscle biopsy was performed and the pathological findings confirmed dermatomyositis. The findings of his chest X-ray and computed tomography showed an increase in the size of the lung cancer lesion. The tumor size decreased, and creatine kinase and lactate dehydrogenase levels also decreased after irinotecan chemotherapy. He was also given prednisolone (1 mg/kg) for prolonged muscle weakness. There are few cases which report dermatomyositis after a diagnosis of SCLC. In the present case, dermatomyositis appeared when the recurrence of SCLC became evident. We believed that the onset of dermatomyositis might be related to the activity level of SCLC.
一名75岁男性于2005年3月被诊断为小细胞肺癌（SCLC）。他接受了由卡铂和依托泊苷组成的化疗，并且对治疗表现出部分缓解。2006年4月，他出现全身疲劳、肌肉和四肢无力、皮肤病变及手指红斑。进行了肌肉活检，病理结果证实为皮肌炎。他的胸部X线和计算机断层扫描结果显示肺癌病灶增大。伊立替康化疗后肿瘤大小减小，肌酸激酶和乳酸脱氢酶水平也降低。他还因长期肌肉无力接受了泼尼松龙（1 mg/kg）治疗。很少有病例报道在SCLC诊断后发生皮肌炎。在本病例中，皮肌炎在SCLC复发明显时出现。我们认为皮肌炎的发病可能与SCLC的活动程度有关。
