Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive MC0358, La Jolla, California 92093-0358, USA.
J Nat Prod. 2010 Apr 23;73(4):679-82. doi: 10.1021/np1000297.
Three new phorbasides (G-I), chlorocyclopropyl ene-yne macrolide glycosides, were isolated from the sponge Phorbas sp. in yields of 7-9.5 mug and fully characterized by MS, CD, and microcryoprobe NMR. The structures of the new compounds differ only in the nature of the sugar residues. The absolute configurations of the new compounds were correlated by ROESY and CD with the parent compounds phorbasides A and B.
从海绵 Phorbas sp. 中分离得到三个新的 phorbasides（G-I），它们是氯环丙烯炔大环内酯糖苷，产率为 7-9.5 μg，并通过 MS、CD 和微探针 NMR 进行了充分的表征。新化合物的结构仅在糖残基的性质上有所不同。新化合物的绝对构型通过 ROESY 和 CD 与母体化合物 phorbasides A 和 B 相关联。
