有机荧光探针发现的启示
Lessons in Organic Fluorescent Probe Discovery.
机构信息
The Department of Chemistry and Biochemistry, Texas State University, San Marcos, USA.
Xenobe Research Institute, P. O. Box 3052, San Diego, CA, 92163-1062, USA.
出版信息
Chembiochem. 2021 Nov 16;22(22):3109-3139. doi: 10.1002/cbic.202100171. Epub 2021 Jun 23.
Abstract
Fluorescent probes have gained profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of fluorophores into fluorescent probes continues to be a robust field for medicinal chemists and chemical biologists, alike. Access to new experimental designs has enabled molecular diversification and led to the identification of new approaches to probe discovery. This review provides a synopsis of the recent lessons in modern fluorescent probe discovery.
摘要
荧光探针在生物技术、药物发现、医学诊断、分子和细胞生物学领域得到了广泛应用。将荧光团转化为荧光探针的方法的发展一直是药物化学家和化学生物学家的一个活跃领域。新的实验设计的出现使分子多样化成为可能，并为探针发现带来了新的方法。本文综述了现代荧光探针发现的最新进展。
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