Pt 催化的 2-烯炔基苯甲醛的水合环化及其在法菲林合成中的应用。
Pt-catalyzed hydrative cyclization of 2-enynylbenzaldehydes and its application to faveline synthesis.
机构信息
Department of Chemistry, Institute of Natural Science, Hanyang University, Sungdong-Gu, Seoul 133-791, Korea.
出版信息
Org Lett. 2010 Mar 19;12(6):1308-11. doi: 10.1021/ol100255z.
PMID:20184345
Abstract
Various 2-[6-en-1-ynyl]benzaldehydes and their analogues were successfully cyclized via Huisgen-type [3+2] cycloaddition to the tetracyclic platinum-carbene complex, which would subsequently undergo hydration to afford the tricyclic products in good yields with excellent stereoselectivities. This hydrative cyclization was also applied to the faveline synthesis.
摘要
各种 2-[6-烯-1-炔基]苯甲醛及其类似物通过 Huisgen 型 [3+2]环加成成功环化，得到四环铂-卡宾配合物，随后进行水合反应，以优异的立体选择性得到高产率的三环产物。该水合环化反应也应用于 faveline 合成。
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