肝素的红外光谱表明，750 - 950厘米-1区域对艾杜糖醛酸残基环构象的变化敏感。
Infrared spectroscopy of heparins suggests that the region 750-950 cm-1 is sensitive to changes in iduronate residue ring conformation.
作者信息
Grant D, Long W F, Moffat C F, Williamson F B
机构信息
Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, Scotland, U.K.
出版信息
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):193-7. doi: 10.1042/bj2750193.
Abstract
By careful definition of polymer environment, heparin i.r. spectra were examined in a region (750-950 cm-1) in which sulphate half-ester absorptions occur. Changes seen in this region when metal ion-heparin complexes are converted into heparinic acid, when heparin is carboxy-group-reduced and when various concentrations of Li(+)-heparin are examined are tentatively interpreted in terms of changes in the ring conformation of iduronate residues.
摘要
通过对聚合物环境的精确界定，对肝素的红外光谱在硫酸盐半酯吸收出现的区域（750 - 950厘米⁻¹）进行了检测。当金属离子 - 肝素复合物转化为肝素酸时、当肝素的羧基被还原时以及当检测不同浓度的锂（⁺） - 肝素时，在该区域观察到的变化，初步从艾杜糖醛酸残基的环构象变化方面进行了解释。
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