Department of Science and Technology, Institute of Materials Engineering, Doctoral School, University of Silesia, Bankowa 14, 40-007 Katowice, Poland.
Department of Science and Technology, Institute of Materials Engineering, Bankowa 14, 40-007 Katowice, Poland.
Molecules. 2024 Mar 29;29(7):1531. doi: 10.3390/molecules29071531.
Nowadays, drug delivery systems (DDSs) are gaining more and more attention. Conducting polymers (CPs) are efficiently used for DDS construction as such systems can be used in therapy. In this research, a well-known CP, polypyrrole (PPy), was synthesized in the presence of the polysaccharide heparin (HEP) and chlorpromazine (CPZ) using sodium dodecyl sulfate (SDS) as electrolyte on a steel substrate. The obtained results demonstrate the successful incorporation of CPZ and HEP into the polymer matrix, with the deposited films maintaining stable electrochemical parameters across multiple doping/dedoping cycles. Surface roughness, estimated via AFM analysis, revealed a correlation with layer thickness-decreasing for thinner layers and increasing for thicker ones. Moreover, SEM images revealed a change in the morphology of PPy films when PPy is electropolymerized in the presence of CPZ and HEP, while FTIR confirmed the presence of CPZ and HEP within PPy. Due to its lower molecular mass compared to HEP, CPZ was readily integrated into the thin polymer matrix during deposition, with diffusion being unimpeded, as opposed to films with greater thickness. Finally, the resulting system exhibited the ability to release CPZ, enabling a dosing range of 10 mg to 20 mg per day, effectively covering the therapeutic concentration range.
如今，药物传递系统（DDS）越来越受到关注。导电聚合物（CPs）被有效地用于 DDS 的构建，因为这样的系统可以用于治疗。在这项研究中，一种众所周知的 CP，聚吡咯（PPy），在多糖肝素（HEP）和氯丙嗪（CPZ）的存在下，使用十二烷基硫酸钠（SDS）作为电解质，在钢基底上合成。所得结果表明 CPZ 和 HEP 成功地掺入聚合物基质中，沉积的薄膜在多次掺杂/脱掺杂循环中保持稳定的电化学参数。通过 AFM 分析估计的表面粗糙度与层厚度减小的较薄层和较厚层的增加呈正相关。此外，SEM 图像显示，当 PPy 在 CPZ 和 HEP 的存在下电聚合时，PPy 薄膜的形态发生了变化，而 FTIR 则证实了 CPZ 和 HEP 存在于 PPy 中。由于 CPZ 的分子量低于 HEP，因此在沉积过程中很容易将其整合到较薄的聚合物基质中，扩散不受阻碍，而对于较厚的薄膜则不然。最后，所得到的系统表现出释放 CPZ 的能力，能够实现每天 10 毫克至 20 毫克的剂量范围，有效地覆盖了治疗浓度范围。
