代谢调节的定量分析。一种使用生成树的图论方法。
Quantitative analysis of metabolic regulation. A graph-theoretic approach using spanning trees.
作者信息
Sen A K
机构信息
Department of Chemical Engineering, California Institute of Technology, Pasadena 91125.
出版信息
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):253-8. doi: 10.1042/bj2750253.
Abstract
A graph-theoretic technique using spanning trees is described for the evaluation of Flux Control Coefficients of metabolic pathways. The technique is illustrated by investigating a linear pathway (a) in the absence of feedback and feedforward regulation. (b) with its first enzyme inhibited by the end product and (c) with multiple feedback loops. It is shown that the Flux Control Coefficients of a linear pathway with one or more feedback loops can be derived in a systematic manner by superimposing the effect of the feedback loop(s) on the expressions pertaining to the Flux Control Coefficients of the unregulated pathway.
摘要
描述了一种使用生成树的图论技术来评估代谢途径的通量控制系数。通过研究线性途径（a）在没有反馈和前馈调节的情况下、（b）其第一个酶被终产物抑制以及（c）具有多个反馈环的情况来说明该技术。结果表明，通过将反馈环的影响叠加到与未调节途径的通量控制系数相关的表达式上，可以系统地推导具有一个或多个反馈环的线性途径的通量控制系数。
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1
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J Theor Biol. 1969 Dec;25(3):370-9. doi: 10.1016/s0022-5193(69)80027-5.
2
Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions.生化系统分析。I. 组成酶促反应速率定律的一些数学性质。
J Theor Biol. 1969 Dec;25(3):365-9. doi: 10.1016/s0022-5193(69)80026-3.
3
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength.酶促链的线性稳态处理。一般性质、控制与效应强度。
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4
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Symp Soc Exp Biol. 1973;27:65-104.
5
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