Hofmeyr J H
Department of Biochemistry, University of Stellenbosch, South Africa.
Eur J Biochem. 1989 Dec 8;186(1-2):343-54. doi: 10.1111/j.1432-1033.1989.tb15215.x.
Metabolic control analysis [Kacser and Burns (1973) Symp. Soc. Exp. Biol. 27, 65-104; Heinrich and Rapoport (1974) Eur. J. Biochem. 42, 89-95] leads to a description of the systemic properties of a metabolic system (expressed as control coefficients) in terms of the local kinetic properties of the individual enzyme-catalyzed reactions (expressed as elasticity coefficients). This paper describes a non-algebraic diagrammatic method which generates the mathematical expressions for flux or concentration-control coefficients in terms of elasticity coefficients. According to a set of simple rules, 'flux-control patterns' or 'concentration-control patterns' are drawn on a metabolic diagram. Each control pattern represents a product of elasticity coefficients that occurs as a term in the expression for a control coefficient. The rules also generate the correct sign that precedes each term. The control patterns are then used to build the expressions for control coefficients. The procedure was developed in such a way that each control pattern can be understood in terms of a 'chain of local effects' which shows how a perturbation in the activity of an enzyme is propagated through the metabolic pathway.
代谢控制分析[卡克瑟和伯恩斯（1973年）实验生物学学会专题讨论会论文集27，65 - 104；海因里希和拉波波特（1974年）欧洲生物化学杂志42，89 - 95]导致根据各个酶催化反应的局部动力学性质（以弹性系数表示）来描述代谢系统的系统性质（以控制系数表示）。本文描述了一种非代数图解方法，该方法根据弹性系数生成通量或浓度控制系数的数学表达式。根据一组简单规则，在代谢图上绘制“通量控制模式”或“浓度控制模式”。每个控制模式代表作为控制系数表达式中的一项出现的弹性系数的乘积。这些规则还生成每个项前面的正确符号。然后使用控制模式构建控制系数的表达式。该程序的开发方式使得每个控制模式都可以根据“局部效应链”来理解，该链展示了酶活性的扰动如何通过代谢途径传播。
