Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Epilepsy Behav. 2010 Apr;17(4):478-82. doi: 10.1016/j.yebeh.2010.01.019. Epub 2010 Feb 24.
Chronic temporal lobe epilepsy (TLE) is characterized by the presence of extra-hippocampal brain abnormality and cognitive impairment in both memory and nonmemory domains. However, the link between structural integrity and cognition has not frequently been studied. Forty-six patients with TLE and 61 age-matched controls were studied to determine the predictive relationship between baseline thalamic volume and performance on measures of executive functioning evaluated 4 years later. As expected, the TLE group had lower baseline thalamic volumes than controls and also performed more poorly on measures of executive functioning. Total thalamic volume significantly predicted subsequent performance on all three measures of executive functioning. These findings were maintained when both hippocampal volume and frontal lobe volume were taken into account. These findings add to a growing literature demonstrating a link between extra-hippocampal volume abnormalities and cognitive functioning in TLE.
慢性颞叶癫痫（TLE）的特征是存在海马外脑异常和记忆及非记忆领域的认知障碍。然而，结构完整性和认知之间的联系尚未得到广泛研究。本研究旨在确定基线丘脑体积与 4 年后评估的执行功能测量结果之间的预测关系，对 46 例 TLE 患者和 61 名年龄匹配的对照组进行了研究。正如预期的那样，TLE 组的基线丘脑体积低于对照组，并且在执行功能测量上表现也更差。总的来说，丘脑体积显著预测了所有三个执行功能测量的后续表现。当考虑到海马体积和额叶体积时，这些发现仍然成立。这些发现增加了越来越多的文献，证明了 TLE 中海马外体积异常与认知功能之间的联系。
