内含子 microRNA 基因的偏性宿主。
Biased hosting of intronic microRNA genes.
机构信息
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
出版信息
Bioinformatics. 2010 Apr 15;26(8):992-5. doi: 10.1093/bioinformatics/btq077. Epub 2010 Feb 24.
MOTIVATION
MicroRNAs (miRNAs) are involved in an abundant class of post-transcriptional regulation activated through binding to the 3(') -untranslated region (UTR) of mRNAs. The current wealth of mammalian miRNA genes results mostly from genomic duplication events. Many of these events are located within introns of transcriptional units. In order to better understand the genomic expansion of miRNA genes, we investigated the distribution of intronic miRNAs.
RESULTS
We observe that miRNA genes are hosted within introns of short genes much larger than expected by chance.
IMPLEMENTATION
We explore several explanations for this phenomenon and conclude that miRNA integration into short genes might be evolutionary favorable due to interaction with the pre-mRNA splicing mechanism.
动机
微 RNA（miRNAs）参与了大量通过与 mRNA 的 3'非翻译区（UTR）结合而激活的转录后调控。目前哺乳动物 miRNA 基因的丰富度主要来自基因组复制事件。这些事件中的许多位于转录单元的内含子中。为了更好地了解 miRNA 基因的基因组扩张，我们研究了内含子 miRNA 的分布。
结果
我们观察到 miRNA 基因存在于短基因的内含子中，比随机预期的要大得多。
实现
我们探讨了几种解释这种现象的方法，并得出结论，miRNA 整合到短基因中可能由于与前体 mRNA 剪接机制的相互作用而具有进化优势。
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