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未从挪威 1 型糖尿病环境触发因素（MIDIA）队列研究的粪便样本中检测到 Ljungan 病毒 RNA。

No Ljungan virus RNA in stool samples from the Norwegian environmental triggers of type 1 diabetes (MIDIA) cohort study.

机构信息

Norwegian Institute of Public Health, Oslo, Norway.

出版信息

Diabetes Care. 2010 May;33(5):1069-71. doi: 10.2337/dc09-1951. Epub 2010 Feb 25.

DOI:10.2337/dc09-1951
PMID:20185738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2858177/
Abstract

OBJECTIVE

Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes.

RESEARCH DESIGN AND METHODS

A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children.

RESULTS

No LjV RNA was detected.

CONCLUSIONS

The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes.

摘要

目的

吕宋人病毒（LjV）被认为是 1 型糖尿病的潜在环境因素。本研究旨在检验 LjV 是否与 1 型糖尿病相关。

研究设计与方法

本研究采用巢式病例对照设计，检测挪威环境触发 1 型糖尿病（MIDIA）研究中粪便样本中预糖尿病自身免疫的发展与 LjV 存在之间的任何关联（n=3803）。研究中随访的儿童包括 27 名在采样期间或之后不久发生预糖尿病自身免疫的婴儿、54 名匹配的对照者和 94 名其他儿童。

结果

未检测到 LjV RNA。

结论

这些结果表明 LjV 在幼儿中很少见。LjV 似乎不参与人类 1 型糖尿病的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d22/2858177/e65e5116b0d4/zdc0051082310001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d22/2858177/e65e5116b0d4/zdc0051082310001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d22/2858177/e65e5116b0d4/zdc0051082310001.jpg

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