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1 型糖尿病患儿糖化血红蛋白的种族差异独立于平均血糖。

Racial disparity in A1C independent of mean blood glucose in children with type 1 diabetes.

机构信息

Department of Psychology, Children's Hospital, New Orleans, Louisiana, USA.

出版信息

Diabetes Care. 2010 May;33(5):1025-7. doi: 10.2337/dc09-1440. Epub 2010 Feb 25.

DOI:10.2337/dc09-1440
PMID:20185743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2858167/
Abstract

OBJECTIVE

Mean blood glucose (MBG) and MBG-independent factors both influence A1C levels. Race was related to A1C independent of MBG in adults. The goal of this study was to determine if racial disparity exists in A1C independent of MBG in children with diabetes.

RESEARCH DESIGN AND METHODS

Participants included 276 children with type 1 diabetes. A1C and MBG were obtained from multiple clinic visits, and a hemoglobin glycation index (HGI) (an assessment of A1C levels independent of MBG) was calculated. A1C and HGI were analyzed controlling for age, diabetes duration, and MBG. RESULTS African Americans had statistically significantly higher A1C (9.1 +/- 0.1) and HGI (0.64 +/- 0.11) than Caucasians (A1C 8.3 +/- 0.1, HGI -0.15 +/- 0.07) independent of covariates.

CONCLUSIONS

Because of racial disparity in A1C, which is independent of MBG, we recommend that A1C and MBG be used together to make therapeutic decisions for children with diabetes.

摘要

目的

平均血糖 (MBG) 和 MBG 以外的因素均会影响 A1C 水平。在成年人中，种族与 A1C 独立于 MBG 相关。本研究的目的是确定在儿童糖尿病患者中，是否存在与 MBG 无关的 A1C 种族差异。

研究设计和方法

参与者包括 276 名 1 型糖尿病儿童。从多次就诊中获得 A1C 和 MBG，并计算血红蛋白糖化指数 (HGI)（一种独立于 MBG 评估 A1C 水平的指标）。在控制年龄、糖尿病病程和 MBG 的情况下，对 A1C 和 HGI 进行分析。

结果

非裔美国人的 A1C（9.1 +/- 0.1）和 HGI（0.64 +/- 0.11）明显高于白人（A1C 8.3 +/- 0.1，HGI -0.15 +/- 0.07），独立于协变量。

结论

由于 A1C 存在与 MBG 无关的种族差异，我们建议 A1C 和 MBG 一起用于制定糖尿病儿童的治疗决策。

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