美国儿童和青年成人HbA(1c)水平分布：第三次全国健康与营养检查调查

Distribution of HbA(1c) levels for children and young adults in the U.S.: Third National Health and Nutrition Examination Survey.

作者信息

Saaddine Jinan B, Fagot-Campagna Anne, Rolka Deborah, Narayan K M Venkat, Geiss Linda, Eberhardt Mark, Flegal Katherine M

机构信息

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

出版信息

Diabetes Care. 2002 Aug;25(8):1326-30. doi: 10.2337/diacare.25.8.1326.

DOI:10.2337/diacare.25.8.1326

PMID:12145229

Abstract

OBJECTIVE

To describe the distribution of HbA(1c) levels among children and young adults in the U.S. and to evaluate the effects of age, sex, race/ethnicity, socioeconomic status, parental history of diabetes, overweight, and serum glucose on HbA(1c) levels.

RESEARCH DESIGN AND METHODS

We analyzed HbA(1c) data from the Third National Health and Nutrition Examination Survey, 1988-1994, for 7,968 participants aged 5-24 years who had not been treated for diabetes. After adjusting for the complex sample design, we compared the distributions of HbA(1c) in subgroups and developed multiple linear regression models to examine factors associated with HbA(1c).

RESULTS

Mean HbA(1c) level was 4.99% (SD 0.50%) and varied from 4.93% (95% CI +/-0.04) in non-Hispanic whites to 5.05% (+/-0.02) in Mexican-Americans to 5.17% (+/-0.02) in non-Hispanic blacks. There were very small differences among subgroups. Within each age- group, among men and women, among overweight and nonoverweight subjects, and at any level of education, mean HbA(1c) levels were higher in non-Hispanic blacks than in non-Hispanic whites. After adjusting for confounders, HbA(1c) levels for non-Hispanic blacks (5.15%, 95% CI +/-0.04) and Mexican-Americans (5.01%, +/-0.04) were higher than those for non-Hispanic whites (4.93%, +/-0.04).

CONCLUSIONS

These data provide national reference levels for HbA(1c) distributions among Americans aged 5-24 years and show statistically significant racial/ethnic differences in HbA(1c) levels that are not completely explained by demographic and health-related variables.

摘要

目的

描述美国儿童和青年人群糖化血红蛋白（HbA₁c）水平的分布情况，并评估年龄、性别、种族/族裔、社会经济地位、父母糖尿病史、超重及血糖水平对HbA₁c水平的影响。

研究设计与方法

我们分析了1988 - 1994年第三次全国健康和营养检查调查中7968名年龄在5 - 24岁且未接受糖尿病治疗的参与者的HbA₁c数据。在对复杂样本设计进行校正后，我们比较了各亚组中HbA₁c的分布情况，并建立了多元线性回归模型来研究与HbA₁c相关的因素。

结果

HbA₁c平均水平为4.99%（标准差0.50%），非西班牙裔白人的平均水平为4.93%（95%置信区间±0.04），墨西哥裔美国人的平均水平为5.05%（±0.02），非西班牙裔黑人的平均水平为5.17%（±0.02）。各亚组之间差异非常小。在每个年龄组内，无论男女、超重与非超重受试者以及任何教育水平下，非西班牙裔黑人的HbA₁c平均水平均高于非西班牙裔白人。在校正混杂因素后，非西班牙裔黑人（5.15%，95%置信区间±0.04）和墨西哥裔美国人（5.01%，±0.04）的HbA₁c水平高于非西班牙裔白人（4.93%，±0.04）。