Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Diabetes Care. 2010 Jul;33(7):1449-51. doi: 10.2337/dc09-1498. Epub 2010 Mar 31.
The A1C-Derived Average Glucose study recommended reporting A1C in estimated average glucose (eAG) equivalents. We compared eAG with self-monitored mean blood glucose (MBG) to determine whether eAG is systematically biased due to biological variation in the relationship between MBG and A1C.
MBG and A1C were recorded from charts of 202 pediatric type 1 diabetic patients at 1,612 clinic visits. Patients were divided into groups with low, moderate, or high A1C bias based on a hemoglobin glycation index (HGI).
The mean +/- SD values for MBG versus eAG were as follows: total population, 194 +/- 34 vs. 196 +/- 36 mg/dl; low-HGI group, 186 +/- 31 vs. 163 +/- 20 mg/dl; moderate-HGI group, 195 +/- 28 vs. 193 +/- 19 mg/dl; and high-HGI group, 199 +/- 42 vs. 230 +/- 31 mg/dl.
eAG underestimated MBG in low HGI patients and overestimated MBG in high HGI patients. Disagreement between eAG and MBG downloaded from patient glucose meters will cause confusion if eAG is implemented for clinical use.
A1C 衍生平均血糖研究建议以估计平均血糖（eAG）等效值报告 A1C。我们比较了 eAG 与自我监测平均血糖（MBG），以确定 eAG 是否由于 MBG 和 A1C 之间的关系存在生物学变异而存在系统偏差。
从 202 名儿科 1 型糖尿病患者的图表中记录了 MBG 和 A1C，共 1612 次就诊。根据血红蛋白糖化指数（HGI），患者分为 A1C 偏差低、中或高的组。
MBG 与 eAG 的平均值 +/- SD 值如下：总体人群，194 +/- 34 与 196 +/- 36 mg/dl；低 HGI 组，186 +/- 31 与 163 +/- 20 mg/dl；中 HGI 组，195 +/- 28 与 193 +/- 19 mg/dl；高 HGI 组，199 +/- 42 与 230 +/- 31 mg/dl。
在低 HGI 患者中，eAG 低估了 MBG，在高 HGI 患者中高估了 MBG。如果将 eAG 用于临床使用，那么从患者血糖仪下载的 eAG 与 MBG 之间的不一致将导致混淆。
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