1 型糖尿病患儿的不稳定糖化血红蛋白与血红蛋白糖化指数呈负相关。
Labile A1C is inversely correlated with the hemoglobin glycation index in children with type 1 diabetes.
机构信息
Division of Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children's Hospital of New Orleans, New Orleans, Louisiana, USA.
出版信息
Diabetes Care. 2010 Feb;33(2):273-4. doi: 10.2337/dc08-2220. Epub 2009 Nov 16.
OBJECTIVE
We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG).
RESEARCH DESIGN AND METHODS
We measured SA1C, LA1C, MBG, and a single clinic capillary glucose (CCG) from 152 pediatric patients with type 1 diabetes. Patients were grouped as high, moderate, or low glycators by hemoglobin glycation index (HGI).
RESULTS
LA1C and SA1C were correlated with CCG and MBG. LA1C was not correlated with SA1C (r = 0.06, P = 0.453). LA1C level was significantly associated with glycator group status (P < 0.0019) and CCG (P < 0.0001). Adjusted LA1C levels were highest in the low-HGI patients and lowest in the high-HGI group.
CONCLUSIONS
A conventional model of SA1C being directly correlated with LA1C concentration was not confirmed. Between-patient differences in SA1C at the same MBG may be due to complex intracellular factors influencing formation of SA1C from LA1C.
目的
我们假设不稳定糖化血红蛋白（LA1C）与稳定糖化血红蛋白（SA1C）直接相关，且 SA1C 个体间差异独立于平均血糖（MBG）。
研究设计和方法
我们检测了 152 名 1 型糖尿病患儿的 SA1C、LA1C、MBG 和单次诊所毛细血管血糖（CCG）。根据血红蛋白糖化指数（HGI）将患者分为高、中、低糖化组。
结果
LA1C 与 SA1C 均与 CCG 和 MBG 相关。LA1C 与 SA1C 无相关性（r = 0.06，P = 0.453）。LA1C 水平与糖化组状态显著相关（P < 0.0019）和 CCG（P < 0.0001）。低 HGI 患者的 LA1C 水平显著升高，而高 HGI 组的 LA1C 水平最低。
结论
LA1C 浓度与 SA1C 直接相关的传统模型未得到证实。在相同 MBG 下 SA1C 个体间的差异可能是由于影响 LA1C 形成 SA1C 的复杂细胞内因素所致。
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