Division of Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children's Hospital of New Orleans, New Orleans, Louisiana, USA.
Diabetes Care. 2010 Feb;33(2):273-4. doi: 10.2337/dc08-2220. Epub 2009 Nov 16.
We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG).
We measured SA1C, LA1C, MBG, and a single clinic capillary glucose (CCG) from 152 pediatric patients with type 1 diabetes. Patients were grouped as high, moderate, or low glycators by hemoglobin glycation index (HGI).
LA1C and SA1C were correlated with CCG and MBG. LA1C was not correlated with SA1C (r = 0.06, P = 0.453). LA1C level was significantly associated with glycator group status (P < 0.0019) and CCG (P < 0.0001). Adjusted LA1C levels were highest in the low-HGI patients and lowest in the high-HGI group.
A conventional model of SA1C being directly correlated with LA1C concentration was not confirmed. Between-patient differences in SA1C at the same MBG may be due to complex intracellular factors influencing formation of SA1C from LA1C.
我们假设不稳定糖化血红蛋白（LA1C）与稳定糖化血红蛋白（SA1C）直接相关，且 SA1C 个体间差异独立于平均血糖（MBG）。
我们检测了 152 名 1 型糖尿病患儿的 SA1C、LA1C、MBG 和单次诊所毛细血管血糖（CCG）。根据血红蛋白糖化指数（HGI）将患者分为高、中、低糖化组。
LA1C 与 SA1C 均与 CCG 和 MBG 相关。LA1C 与 SA1C 无相关性（r = 0.06，P = 0.453）。LA1C 水平与糖化组状态显著相关（P < 0.0019）和 CCG（P < 0.0001）。低 HGI 患者的 LA1C 水平显著升高，而高 HGI 组的 LA1C 水平最低。
LA1C 浓度与 SA1C 直接相关的传统模型未得到证实。在相同 MBG 下 SA1C 个体间的差异可能是由于影响 LA1C 形成 SA1C 的复杂细胞内因素所致。
