视杆光转导的失活机制：科根讲座。
Deactivation mechanisms of rod phototransduction: the Cogan lecture.
机构信息
Department of Ophthalmology and Vision Science and Center for Neuroscience, University of California, Davis, California, USA
出版信息
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1282-8. doi: 10.1167/iovs.09-4366.
Abstract
The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.
摘要
视网膜中的视杆和视锥细胞吸收光子会激活同源的生化信号级联反应，从而导致支持视觉初始步骤的电变化。级联反应的持续活动会干扰光感受器对后续光子吸收的信号传递能力，最终限制光感受器的灵敏度和时间分辨率。本文总结了最近在转基因和敲除小鼠视杆细胞上的研究工作，这些工作揭示了正常响应恢复所必需的失活动力学机制，以及这些过程中的每一个如何共同影响视杆细胞闪光反应的整体时程。
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本文引用的文献
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RGS9 concentration matters in rod phototransduction.RGS9的浓度在视杆细胞光转导过程中至关重要。
Biophys J. 2009 Sep 16;97(6):1538-47. doi: 10.1016/j.bpj.2009.06.037.
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Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.增强的抑制蛋白促进恢复并保护缺乏视紫红质磷酸化的视杆细胞。
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Functional comparison of RGS9 splice isoforms in a living cell.活细胞中RGS9剪接异构体的功能比较
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Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction.第二信使在细胞质中的扩散充当脊椎动物光转导中单光子反应的变异性抑制因子。
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Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice.转基因小鼠视杆光感受器中视觉抑制蛋白的功能比较。
Invest Ophthalmol Vis Sci. 2007 May;48(5):1968-75. doi: 10.1167/iovs.06-1287.
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RGS expression rate-limits recovery of rod photoresponses.RGS的表达对视杆光反应的恢复起到限速作用。
Neuron. 2006 Aug 17;51(4):409-16. doi: 10.1016/j.neuron.2006.07.010.
7
Multiple phosphorylation sites confer reproducibility of the rod's single-photon responses.多个磷酸化位点赋予视杆细胞单光子反应的可重复性。
Science. 2006 Jul 28;313(5786):530-3. doi: 10.1126/science.1126612.
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Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.通过单细胞记录得到的野生型小鼠S-和M-视锥光感受器的生理特征。
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9
Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.抑制蛋白剪接变体对磷酸化和非磷酸化视紫红质的失活作用。
J Neurosci. 2006 Jan 18;26(3):1036-44. doi: 10.1523/JNEUROSCI.3301-05.2006.
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